Abstract: Multiple myeloma (MM) is characterized by an abnormal rise in monoclonal immunoglobulins, accounting for around 10% of all hematologic malignancies. Individuals with MM face an elevated risk of both arterial and venous thrombosis, which is believed to result from a combination of patient comorbidities, the hypercoagulable state caused by the disease, and the effects of certain treatments. This case describes acute ischemic stroke as a presenting manifestation of MM. A 69-year-old female with a history of MM presented with loss of consciousness and right lateralization, suggesting acute ischemic stroke. We present a case of a 69-year-old female who was admitted with sudden loss of consciousness. Upon examination, she exhibited a GCS of E2V4M5 and neurological signs indicative of right lateralization. Initial laboratory results revealed mild anemia, leukopenia, and electrolyte imbalances, including moderate hypokalemia and hyponatremia. A CT scan of the brain on the day of admission revealed a subacute ischemic infarction in the left external capsule, cerebral atrophy, and mild hydrocephalus. After an extensive evaluation, common stroke etiologies were ruled out, resulting in a final diagnosis of cerebral infarction associated with MM. MM is a known risk factor for stroke due to chemotherapy, patient-related factors like advanced age and immobilization, and tumor-related factors such as increased plasma viscosity and a hypercoagulable state. The patient’s clinical presentation and imaging findings emphasize the need for heightened awareness of stroke as a potential first manifestation of MM, particularly in older adults.
Keywords: acute ischemic stroke, multiple myeloma, thrombosis, hypercoagulability.
Title: ISCHEMIC STROKE AS A RARE PRESENTATION OF MULTIPLE MYELOMA IN A 69-YEAR-OLD FEMALE PATIENT
Author: Made Astri Asvinia, I Gusti Agung Ayu Ary Indah Pertiwi, I Ketut Sumada, Desie Yuliani, Ni Made Kurnia Dwijayanthi
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Vol. 13, Issue 1, April 2025 - September 2025
Page No: 275-277
Research Publish Journals
Website: www.researchpublish.com
Published Date: 19-June-2025
